Russian doctors pioneer new Alzheimer’s treatment strategy

Sechenov University scientists have developed and successfully tested a new blood-filtering technique targeting inflammation linked to brain-cell damage

Russian doctors have developed and tested what they describe as the first treatment strategy of its kind for Alzheimer’s, using a new blood-filtering technique to target chronic inflammation – one of the processes believed to drive brain-cell damage.

Alzheimer’s is a progressive brain disease and the most common form of dementia. It gradually destroys memory, thinking and other cognitive abilities, eventually leaving patients unable to perform everyday tasks independently.

The new method was developed by clinicians at Sechenov University in Moscow, one of Russia’s oldest and leading medical universities, and tested on Alzheimer’s patients, according to a press release issued on Tuesday.

Unlike most existing treatments, which largely seek to ease symptoms or target beta-amyloid – a harmful protein that accumulates in the brain of Alzheimer’s patients – the new approach focuses on substances that fuel inflammation throughout the body and are believed to contribute to the disease.

Among them are so-called neutrophil extracellular traps (NETs) – web-like structures of DNA and enzymes released by immune cells to fight health threats. While normally part of the body’s defenses, researchers say an excess of NETs with age can fuel inflammation, increase blood-vessel permeability, promote beta-amyloid buildup and damage brain cells.

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According to Natalia Sivtsevich, head of the university hospital’s transfusiology department, the Sechenov team hypothesized that removing some of these structures from the bloodstream could reduce inflammation and potentially slow processes contributing to Alzheimer’s.

To do so, they developed a technique that essentially cleans the blood. A patient’s plasma is passed through a special filter that removes potentially harmful DNA-containing particles while preserving healthy proteins, minerals and other useful substances before being returned to the bloodstream.

The approach was tested in a pilot study involving patients diagnosed with Alzheimer’s. They underwent three blood-filtering procedures at intervals of two to three days, with each session processing the equivalent of twice the patient’s total circulating plasma volume.

Doctors assessed the patients before and after treatment using memory and cognitive tests, brain MRI scans and spinal-fluid biomarkers. Three months later, researchers reported improvements in verbal memory, attention and information-processing speed. Relatives asked to assess the patients’ progress also noted improvements in their ability to perform daily tasks.

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Existing Alzheimer’s treatments either support memory, prevent damaging brain-cell overstimulation, or target beta-amyloid buildup. However, their effectiveness is limited and side effects can be significant, while none address the disease’s underlying causes, according to Vladimir Parfenov, director of Sechenov University’s Kozhevnikov Clinic of Nervous Diseases.

The researchers stressed that the findings are preliminary and that larger trials are needed to confirm the treatment’s safety and effectiveness. However, the team believes the strategy could eventually complement existing Alzheimer’s therapies.

Around 57 million people worldwide live with dementia, with Alzheimer’s accounting for an estimated 35–40 million cases, according to the World Health Organization (WHO). Dementia is the seventh-leading cause of death globally, with nearly 10 million new cases each year – roughly one every three seconds. The risk of developing the condition doubles every five years after age 65. There is currently no cure.