'Remember the Titans' star Ethan Suplee issues warning about weight loss drug craze

Ethan Suplee pumped the brakes on the GLP-1 craze, warning that the wildly popular weight-loss drugs aren't the miracle fix many people believe they are.

As millions of Americans continue turning to blockbuster GLP-1 medications, Suplee said the drugs are only one piece of the puzzle. Drawing from his own decades-long weight-loss journey, the actor said sustainable success comes from building healthier habits instead of relying on medication alone.

Suplee has been candid about his decades-long battle with obesity. The "Remember the Titans" actor weighed roughly 500 pounds at his heaviest and ultimately lost around 300 pounds through years of diet and lifestyle changes. He has also undergone multiple skin-removal surgeries and now hosts weekly discussions on his show, "LifeLONG with Ethan Suplee," about long-term weight management.

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The 50-year-old actor started dieting at just five years old and later, by his own volition, at age 24. "And I kind of spun my wheels for 15 years on these yo-yo diets simply because I didn't communicate," Suplee told Fox News Digital. "And when I didn't communicate to anyone else, I didn't actually figure out what I really wanted."

After decades of trial and error, Suplee said his own experience taught him there isn't a shortcut to lasting weight loss. While he acknowledged the weight-loss drugs can be an effective tool, he argued they aren't a replacement for building healthier habits.

"As a kid, I wanted a magical diet drug so badly. And now we have what is a magical diet drug," he said. "I think, unfortunately, it's also not a one-stop shop. I think you can hop on a GLP-1 and experience weight loss. You can see the scale go down week over week for a long time without having to do anything else."

"... I think when people imagine their ideal — I don't think the GLP-1s get anyone to their ideal."

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Suplee emphasized that the medications can dramatically improve people's health and said he wouldn't discourage anyone from using them.

"By the way, a small amount of weight loss provides a huge health benefit," he added. "So if you're just going into it, going like, 'I just want to be healthier. Let me hop on this GLP-1 agonist and improve my health.' Bravo to you. You're going to do that ... I'm not criticizing those people."

But Suplee said the conversation becomes more nuanced for people hoping to reach an "ideal" weight or transform their physique.

"I think for those people, just hopping on a GLP-1 is not enough," Suplee added. "I think it also will require some resistance training to preserve lean tissue ... maybe increase protein a bit ... I just think [they] aren't a one-stop shop."

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The "My Name is Earl" star said his own experience ultimately shaped a simple philosophy: There's no single answer when it comes to long-term weight loss. He said lasting success comes from addressing the many factors that influence a person's health and relationship with food.

"I don't think it's ever going to be one thing," Suplee explained. "I think it is partially the amount of food you're consuming, partially the types of food you're consuming, partially how sedentary you are, and partially your emotional and potentially mental behavior and relationship with food."

"There's an ecosystem to everybody's life."

It's a lesson Suplee said became even clearer after he reached his goal weight.

"I found maintaining weight loss to be a hell of a lot harder and more complicated than losing weight," he admitted.

Suplee said he still grapples with the same cravings he experienced before losing roughly 300 pounds.

"If I see an advertisement for McDonald's, I want McDonald's," he said. "I'm hungry. This is true today as it was 20 years ago."

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He was quick to clarify that long-term weight maintenance isn't about completely cutting out fast food, including McDonald's.

"But it's not eating it emotionally, not eating it to cure my anxiety, not eating it out of compulsion, and then not overeating it," Suplee added. "Like, these are all the factors I have to deal with to maintain my weight."

When asked what has allowed him to maintain his weight loss over the years, Suplee pointed to a less obvious factor: learning to be honest with himself by opening up to others.

"I found I could become more honest with myself by opening up and being honest with other people," Suplee said. "And I think that really made a huge difference in my ability to maintain this weight loss as long as I have."